- Ctrl+ Shift + V: Paste without formatting.
- Shift + F10: Display the shortcut menu for the selected item.
- Ctrl + Shift + N: Create a new folder in File Explorer.
- Ctrl + Shift + E: Display all folders above the selected folder in the File Explorer.
- Ctrl + Shift: Switch the keyboard layout when multiple keyboard layouts are available.
- Ctrl + Shift + Esc: Open the Task Manager.
- Windows key + Shift + V: Cycle through notifications in reverse order.
- Shift + click a taskbar icon for an app: Open an app or quickly open another instance of an app.
- Ctrl + Shift + click a taskbar icon for an app: Open an app as an administrator.
- Shift + Right-click a taskbar icon for an app: Show the window menu for the app.
- Shift + Right-click a grouped taskbar icon for an app: Show the window menu for the group
- Windows key + Shift + a number from 1-9: Start a new instance of the app pinned to the taskbar in the position indicated by the number.
- Windows key + Ctrl + Shift + a number from 1-9: Open a new instance of the app located at the given position on the taskbar as an administrator.
- Windows key + Shift + Up arrow: Stretch the desktop window to the top and bottom of the screen.
- Windows key + Shift + Down arrow: Restore/minimize active desktop windows vertically, maintaining width.
- Left Alt + Left Shift + Num Lock: Turn Mouse Keys on or off.
- Shift + Delete: Permanently delete all files.
Source: makeuseof.com